Goals of this work lye in attempts to fabricate Ag2O-TeO2-V2O5 glasses (Gs) and glass-ceramics (GCs), determination of the mean square lattice strain and dislocation density by using Williamson-Smallman method and specially detection of their antibacterial activity against two gram-negative bacteria of Escherichia coli and Kelbesiella pneumoniae and also two gram-positive bacteria of Staphylococcus aureus and Bacillus cereus. The xAg2O-40TeO2-(60-x)V2O5 (0≤ x≤50 mole %) ternary glasses, were obtained using the melt quenching method and so, resulted glasses were annealed at their specified crystallization temperature (Tcr) to achieve the glass-ceramics. Then, the Williamson-Smallman method was used to determine the mean square lattice strain and dislocation density. Further structural investigations were done by FESEM, EDX and TEM. Also, serial dilution bioassay was performed against both before-mentioned gram positive and gram negative bacteria (as test strains) to assess their antibacterial activity. Results show that the highest antibacterial and bactericidal potential is devoted to G and GCs sample with x=30, as the optimal Ag2O content. Moreover, the antibacterial activity of the Gs and GCs on Staphylococcus aureus bacteria is higher than Bacillus cereus bacteria and in the case of gram negative’s, Escherichia coli exhibit a more inhibition and bactericidal effect at x= 30 %; in brief, the studied samples are good candidates in biological applications.
