The use of vermicompost as a biological fertilizer under salinity stress conditions was tested in this research. Accordingly, the seeds of Medicago rigidula were grown in the greenhouse. The experiment was performed based on factorial arrangement in a completely randomized design using 5 replications. Application rates of vermicompost were 0, 10, 20 and 30%. Salinity stress was conducted in three levels (0, 50 and 100 mM sodium chloride (NaCl)). The highest and the lowest values of the plant survival capacity (%), shoot dry weight (g), leaf relative water content (LRWC) (%), total chlorophyll content (%), leaf area (cm2), total nitrogen content (TNC) (%) and potassium (K) content (%) of the plant tissues were found in VC4 × SL1 and VC1 × SL3 treatments, respectively. Whereas, the maximum and minimum values of root dry weight and root:shoot ratio were seen in VC1 × SL3 and VC4 × SL1 treatments, respectively.