A study evaluated effects of supplementing a barley–corn–soybean meal-based diet with a multi-enzyme product on growthperformance and nutrient digestibility of weaned pigs. A total of 122 pigs (initial body weight of 5.2 kg ± 0.98) were group-housed in 24 pens of 5–6 barrows or 6–7 gilts per pen. Pigs were fed two diets: basal diet without or with a multi-enzyme blendthat supplied 4000 U of xylanase, 150 U of β-glucanase, 1000 U of amylase, and 500 U of protease per kilogram of diet. Thediets were fed for 6 weeks in two phases: Phase 1 for the first 3 weeks and Phase 2 for the last 3 weeks. Growth performancewas determined by phase, whereas apparent total tract digestibility of nutrients was determined at the end of the experiment.Multi-enzyme did not affect body weight gain, but improved (P < 0.05) gain-to-feed ratio by 5.4% for the entire study period.Multi-enzyme increased (P < 0.05) apparent total tract digestibility of gross energy, neutral detergent fiber, and acid detergentfiber by 2.7%, 20.7%, and 41.9%, respectively. In conclusion, the test multi-enzyme product can improve feed efficiency ofweaned pigs, likely through improved digestibility of dietary fiber components.