In recent years, the use of medicinal plants to improve health conditions has gained significant attention, particularly for their role in alleviating respiratory issues, treating infections, minimizing the side effects of synthetic chemical compounds, and combating bacterial resistance to antibiotics. Passionflower is recognized as a valuable medicinal plant due to its potential antimicrobial properties. The plant is known for its rich content of bioactive compounds, including flavonoids and alkaloids, which contribute significantly to its antibacterial activity. These compounds play a crucial role in inhibiting bacterial growth, making them a promising natural alternative to conventional chemical antimicrobial agents. This study aims to explore the antimicrobial effects of extracts derived from the floral parts of Passiflora caerulea against a range of human pathogenic bacteria, highlighting its potential as a natural source of antibacterial agents. The antibacterial properties of the floral extracts of the P. Caerulea were tested against four human pathogenic bacteria, Pseudomonas aeruginosa, Escherichia Coli, Staphylococcus aureus and Streptococcus pyogenes, by broth microdilution method. The dried flower extractions of P. Caerulea were performed using four solvents: acetone, ethanol, methanol, and water. Minimum Inhibitory concentration (MIC) and Minimum Bactericidal concentration (MBC) were measured to evaluate the antibacterial effects of P. Caerulea extracts. The analyzed results showed that the acetone extract has the highest growth inhibition rate against the tested bacterial species. Therefore, the study’s findings could serve as a basis for developing novel therapeutic strategies against pathogenic microbes, thereby advancing future pharmaceutical innovations.
