Introduction: This study aimed to evaluate the effectiveness of three therapeutic interventions, acceptance and commitment therapy (ACT), cognitive rehabilitation (CR), and motivational interviewing (MI), on cognitive indices in male cannabis users. Methods: A quasi-experimental design was employed, involving 60 male participants aged 20-30, who were divided into three intervention groups (15 each) and one control group. Cognitive indices were assessed using the Forward and Backward Digit Span Task, N-Back Task, Stroop Test, Go/No-Go Task, Iowa Gambling Task, and Stop Signal Task. Results: The mean scores for correct responses and reaction times in the ACT, CR, MI, and control groups were 73.9 (763.9 ms), 70.9 (681.7 ms), 70.2 (770.0 ms), and 64.0 (794.2 ms), respectively. Presentation errors were recorded as 3.5, 3.6, 3.6, and 4.0, while deletion errors were 3.6, 3.8, 3.8, and 4.2. Decision-making scores were 1469.8, 1478.3, 1484.7, and 1508.5, whereas information processing speeds were 32.0, 29.0, 30.4, and 26.3. Although differences among interventions were not statistically significant at individual time points (P>0.05), longitudinal analysis indicated significant cognitive improvements over time (P<0.0001). Conclusion: ACT emerged as the most effective intervention, highlighting its potential to ameliorate cognitive impairments associated with chronic cannabis use. These findings underscore the necessity of targeted therapeutic strategies for cannabis users.
