Background & Aims of the Study: Due to the increasing pollution of water resources, tow documented methods: the Heavy metal potential index (HPI) and the Heavy metal evaluation index (HEI) were evaluated for their suitability for contamination monitoring of heavy metals (As, Zn, Pb, Cd and Cu) contamination in groundwater resources of Asadabad Plain during spring and summer in 2012. Materials & Methods: In this analytical observational study, concentrations of heavy metals have been evaluated at 30 important groundwater sampling stations. For this purpose, collect samples in pre-cleaned, acid-soaked polyethylene bottles. Add 2 mL conc HNO3 /L sample and mix well. Cap tightly and store in refrigerator until ready for analysis. Metal concentrations were determined using inductively coupled plasma- optical emission spectrometry (ICP-OES). Results: The results showed that mean concentrations of As, Zn, Pb, Cd and Cu in groundwater samples in spring season were 52.53±13.62, 15.51±23.45, 10.10±2.80, 4.48±1.80 and 8.63±10.87 μg l−1, respectively and in summer season were 57.60±16.90, 14.99±17.66, 9.28±2.46, 4.57±1.73 and 10.45±10.30 μg l−1, respectively. Therefore the mean values of indices in samples from spring and summer seasons were 25.61 and 27.28 respectively for HPI and were 9.29 and 8.88 respectively for HEI, and indicates low contamination levels. Comparing the mean concentrations of the evaluated metals with WHO permissible limits showed a significant difference (P<0.05). Thus, the mean concentrations of the metals were significantly lower than the permissible limits. Conclusions: Despite of the heavy metal pollution of the groundwater resources in Asadabad Plain is lower than WHO permissible limits, but the irregular and long-term usage of agricultural inputs, use of wastewater and sewage sludge in agriculture, over use of organic fertilizers and establishment of pollutant industries can threaten the groundwater resources of this region and cause adverse effect