In this paper, the post-processing of 3D-printed poly lactic acid (PLA) parts is investigated. Workpieces are manufactured by fused deposition modeling (FDM) 3D printing, while they may have defects in some areas such as edges. A post-processing is introduced here for 3D-printed samples by low power CO 2 laser. The thickness of the FDM samples are 3.2 mm and printed by optimum conditions. E ects of process parameters such as focal plane position ( 3.2–3.2 mm), laser power (20–40 W), and laser cutting speed (1–13 mm/s) are examined based on the design of experiments (DOE). Geometrical features of the kerf; top and bottom kerf; taper; ratio of top to the bottom kerf are considered as output responses. An analysis of the experimental results by statistical software is conducted to survey the e ects of process parameters and to obtain regression equations. By optimizing of the laser cutting process; an appropriate kerf quality is obtained and also optimum input parameters are suggested. Experimental verification tests show a good agreement between empirical results and statistical predictions. The best optimum sample with 1.19 mm/s cutting speed, 36.49 W power and 0.53 mm focal plane position shows excellent physical features after the laser cutting process when 276.9 m top and 261.5 m bottom kerf width is cut by laser.