Abstract Aim: The purpose of this article was to review the effects of cardiac rehabilitation and exercise on cardiovascular disease. Heart disease is one of the most common diseases in the world. There is a negative relationship between mortality and physical activity level in cardiac patients. Rehabilitation is an important and effective part of cardiac care which, in addition to controlling the disease, slows its progress and improves symptoms, Nowadays; modern science in the field of medical and therapeutic programs has made a great effort to perform the exercises in the form of cardiac rehabilitation programs under the supervision of specialist physiologists and exercise physiologists. Materials and methods: Google Scholar, PubMed, Scopus databases were searched for articles. Results and Conclusion: Performing cardiac rehabilitation activities by cardiac patients enables them to perform daily living tasks and exercise improves their functional ability, on the other hand, the rate of participation in a sports rehabilitation program is inversely proportional to mortality, and cardiac rehabilitation, along with regular exercise, plays a role in stopping the process of heart disease and reducing its associated symptoms and improving mental health and enhancing functional capacity and returning to life without dependence on others and most importantly reducing mortality. Determining the type, severity, frequency, necessity of monitoring sports rehabilitation specifically with regard to the symptoms shown by the patient improves high intensity exercise, cardiac function and athletic ability.