03 خرداد 1403
محمود ناصري

محمود ناصری

مرتبه علمی: دانشیار
نشانی:
تحصیلات: دکترای تخصصی / فیزیک-نانو
تلفن: 08132355404
دانشکده: دانشکده علوم پایه

مشخصات پژوهش

عنوان
In vitro and in silico investigations by two new pH sensitive magnetic ferrate nanocarriers for delivery of 5-fluorouracil and chlorambucil
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها
Ferrate nanocomposite;Drug delivery ;MTT assay ; Thermal treatment method
سال
2023
مجله JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
پژوهشگران محمود ناصری ، مریم رحیمی

چکیده

In the preset study, potassium-calcium ferrate (KCaFeO4) and sodium-calcium ferrate (NaCaFeO4) nanoparticles were synthesized by thermal treatment method and the KCaFeO4@GO and NaCaFeO4@SiO2 nanocomposites were obtained by chemical processes. Different characterization techniques, such as X-ray diffraction (XRD), field emission scanning electron microscope (FE-SEM) coupled with energy dispersive X-ray spectroscopy (EDX), transmission electron microscopy (TEM) and Fourier transform infrared (FT–IR) spectroscopy were investigated to confirm the degree of crystallinity, microstructure, elemental analysis, morphology, and phase composition respectively. The prepared ferrate nanocomposites was used as a drug delivery carrier for 5-fluorouracil (5-FU) and chlorambucil (CLB) drugs. These drugs were loaded in to mentioned ferrate nanocomposites to compare effectiveness and cytotoxicity against the cancer and healthy cells. The cytotoxicity and anticancer activity of the drug against the MCF-7 cells were estimated by MTT assay. Results showed prepared drug loaded ferrate nanocomposites clearly decrease cell toxicity of loaded chemotherapeutic agents and these are two samples based 5-FU and CLB drugs are economically efficient drugs for curing breast cancer.