محمود ناصری

In the preset study, potassium-calcium ferrate (KCaFeO4) and sodium-calcium ferrate (NaCaFeO4) nanoparticles were synthesized by thermal treatment method and the KCaFeO4@GO and NaCaFeO4@SiO2 nanocomposites were obtained by chemical processes. Different characterization techniques, such as X-ray diffraction (XRD), field emission scanning electron microscope (FE-SEM) coupled with energy dispersive X-ray spectroscopy (EDX), transmission electron microscopy (TEM) and Fourier transform infrared (FT–IR) spectroscopy were investigated to confirm the degree of crystallinity, microstructure, elemental analysis, morphology, and phase composition respectively. The prepared ferrate nanocomposites was used as a drug delivery carrier for 5-fluorouracil (5-FU) and chlorambucil (CLB) drugs. These drugs were loaded in to mentioned ferrate nanocomposites to compare effectiveness and cytotoxicity against the cancer and healthy cells. The cytotoxicity and anticancer activity of the drug against the MCF-7 cells were estimated by MTT assay. Results showed prepared drug loaded ferrate nanocomposites clearly decrease cell toxicity of loaded chemotherapeutic agents and these are two samples based 5-FU and CLB drugs are economically efficient drugs for curing breast cancer.