The present study describes the development of a novel nanocomposite, consisting of palladium nanoparticles (Pd NPs) immobilized on the surface of polydopamine (PDA)-modified TiO2 microparticles (TiO2/PDA-Pd NPs). The physical and chemical characteristics of the synthesized TiO2/PDA-Pd nanocomposite were analyzed using different techniques, such as FT-IR, FE-SEM, EDX, TEM, XPS, and ICP-OES. This TiO2/PDA-Pd NPs nanocomposite was then investigated for its catalytic application in the Suzuki-Miyaura coupling reaction, yielding biphenyl products with good efficiency. Furthermore, the nanocatalyst exhibited exceptional catalytic performance, maintaining its high activity after seven reaction cycles, highlighting its potential for use as a sustainable and recyclable catalyst.