2024 : 12 : 24
Mohammad Satari keykeleh

Mohammad Satari keykeleh

Academic rank: Assistant Professor
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Education: PhD.
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Faculty: science
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Research

Title
Diabetic wound healing function of PCL/cellulose acetate nanofiber engineered with chitosan/cerium oxide nanoparticles
Type
JournalPaper
Keywords
Cellulose acetate; Cerium oxide nanoparticles; Chitosan; Electrospraying; Electrospun nanofibers; Poly (ɛ-caprolactone); Wound healing
Year
2024
Journal INTERNATIONAL JOURNAL OF PHARMACEUTICS
DOI
Researchers Mohammad Satari keykeleh

Abstract

The use of cerium oxide nanoparticles (CeO2NPs) in diabetic wound repair substances has shown promising results. Therefore, the study was conducted to introduce a novel nano-based wound dressing containing chitosan nanoparticles encapsulated with green synthesized cerium oxide nanoparticles using Thymus vulgaris extract (CeO2-CSNPs). The physical properties and structure of the nanoparticles were analyzed using XRD, DLS, FESEM and FTIR techniques. The electrospun PCL/cellulose acetate-based nanofiber was prepared and CeO2-CSNPs were integrated on the PCL/CA membrane by electrospraying. The physicochemical properties, morphology and biological characteristics of the electrospun nanocomposite were evaluated. The results showed that the nanocomposite with 0.1 % CeO2-CSNPs exhibited high antibacterial performance against S. aureus (<58.59 µg/mL). The PCL/CA/CeO2-CSNPs nanofiber showed significant antioxidant activity up to 89.59 %, cell viability improvement, and cell migration promotion up to 90.3 % after 48 h. The in vivo diabetic wound healing experiment revealed that PCL/CA/CeO2-CSNPs nanofibers can significantly increase the repair rate of diabetic wounds by up to 95.47 % after 15 days. The results of this research suggest that PCL/CA nanofiber mats functionalized with CeO2-CSNPs have the potential to be highly effective in treating diabetes-related wounds.