Background and purpose: Considering the many benefits of fish in the food basket, the purpose of this study was to examine the risk assessment effects of heavy metals from Dez river fish. Materials and Methods: 80 samples were caught from the local species of Dez River, they were acid digested; afterwards, they were analyzed by atomic absorption spectrometry. Results: The results showed that there was a positive correlation between accumulating metals and condition factor, especially with regard to zinc and cadmium; this correlation was more likely to be observed for the Capoeta trutta species. Also, comparing the daily and weekly intake of heavy metals with the rate limits of PTDI has shown that the absorption value of metals were considerably lower than the specified limit. Conclusion: The high level of CRlim showed safe consumption of fish in Dez River considering the potential health risk. Zinc and cadmium played an important role in finding out the TTHQ index. The Capoeta trutta and Carasobarbus luteus species had the most and least amounts of TTHQ index. Finally, comparing the means of metal concentrations with standard ones has shown that the concentrations of zinc and cadmium were higher than the global standards.