Curcumin and its derivatives were considered as the potent bioactive compounds. In the present study, a curcumin derivative was grafted on graphene surface to form the new hybrid GN-CP. Fourier-transform infrared spectroscopy and scanning electron microscopy confirmed the formation of synthesized nonomaterial. The antibacterial and antioxidant activities of nanocomposite were conducted in vitro assays, and results showed that GN-CP had better antibacterial activity and acceptable antioxidant capabilities in compare of curcumin and graphene.