This study presents experimental density and viscosity data for methyl butanoate + 2-alkanol (2-propanol to 2-hexanol) mixtures at 0.1 MPa and within the temperature range of 293.15 K to 323.15 K. The Redlich-Kister model successfully represented the experimental data for both derived properties (excess molar volume and viscosity deviation). The results indicate weak attractive forces and a contraction effect in the binary mixtures. In addition, the PC-SAFT model accurately predicted the density of the mixtures, while Eyring’s theory provided an effective modeling of the viscosity behavior.