To obtain the new perspectives on the molecular interactions in the binary systems of butanone and a homologous series of 1-alkanol from 1-pentanol up to 1-decanol, these mixtures were studied using the Kirkwood–Buff (KB) formalism and preferential solvation analysis. The results were confirmed using the experimental excess molar volumes. KB integralsGij, the excess or deficit number nij, and solvation coefficients ijare reported here. Analysis of obtained data regarding the KB formalism and preferential solvation reveals that interactions strength in mixtures depends on the butanone concentration and size of 1-alkanol. Also, interactions between similar molecules are remarkable and become stronger as the length of the alcohol increases. Furthermore, mixtures structure was studied using the concentration-concentration structure factor, SCC (0). Results from application of this parameter show that the homocoordination occurs in solutions. Steric effects lead to the stronger orientations in the mentioned mixtures.
