09 خرداد 1403
محمود ناصري

محمود ناصری

مرتبه علمی: دانشیار
نشانی:
تحصیلات: دکترای تخصصی / فیزیک-نانو
تلفن: 08132355404
دانشکده: دانشکده علوم پایه

مشخصات پژوهش

عنوان
The Effect of Calcination Temperature on the Anticancer Activity of CaFe2O4@ PVA Nanocarriers: Photodynamic Therapy and Drug Delivery Study
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها
Photodynamic therapy · Calcium · Curcumin · Magnetite · PVA · Drug delivery
سال
2020
مجله Journal of Inorganic and Organometallic Polymers and Materials
پژوهشگران محمود ناصری

چکیده

In this project, Calcium ferrite/polyvinyl alcohol ( CaFe2O4@PVA) nanocarriers were prepared by a thermal-treatment method at three different temperatures (773, 823 and 923 K). The nanocarriers were used as drug delivery systems (DDS) to deliver curcumin (CUR) and were utilized as a new structure for photo dynamic therapy (PDT). Drug loading and release study of CUR were performed and it was observed that nanocarriers showed a pH dependent drug release behavior. MTT assay, Hemolysis assay and lethal dose test were applied to determine the cytotoxicity of nanocarriers. These tests indicated that synthesized nanocarriers can be considered as nontoxic. Also, the photodynamic therapy experiments were performed by two groups: one group of cells were treated by different concentrations of nanocarriers without light and the other group were exposed to light. Then, the efficacy of PDT was determined by MTT and it was revealed that whenever nanocarriers were exposed to light the cytotoxicity was significantly high. Therefore, it was revealed that these nanocarriers are suitable to be utilized as a drug delivery systems and photo dynamic therapy agent.