03 خرداد 1403
محمود ناصري

محمود ناصری

مرتبه علمی: دانشیار
نشانی:
تحصیلات: دکترای تخصصی / فیزیک-نانو
تلفن: 08132355404
دانشکده: دانشکده علوم پایه

مشخصات پژوهش

عنوان
Improving the anti-cancer activity of quercetin-loaded AgFeO2 through UV irradiation: Synthesis, characterization, and in vivo and in vitro biocompatibility study
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها
Drug delivery UV light Biocompatibility Quercetin Delafossite
سال
2020
مجله JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
پژوهشگران محمود ناصری

چکیده

The present study aimed to synthesize AgFeO2 nanocarriers by a thermal treatment method and to test them with respect to their applicability in photodynamic therapy and drug delivery of anti-cancer drugs. Chemical structure, surface morphology, and magnetic properties of AgFeO2 were studied by X-ray diffractometer, Field emission-scanning electron microscopy, Fourier-transform infrared spectroscopy, and vibrating-sample magnetometer. The X-ray data for AgFeO2 indicated the typical patterns of rhombohedral phase with delafossite structure. The biocompatibility of AgFeO2 was evaluated by a hemolysis test and a lethal dose test. The results confirmed the non-toxicity of the nanoparticles when used in photodynamic therapy. The loading and encapsulation efficiency of AgFeO2 were 20.23 ± 0.24 and 84.55 ± 1.24, respectively. Furthermore, when the pH of the release media decreased from 7.4 to 5.8, the release rate of the Quercetin from Quercetin loaded AgFeO2 increased from 52 to 70%. In the photodynamic therapy, the cytotoxicity of Quercetin, AgFeO2 and Quercetin-loaded AgFeO2 on tumor cells was studied. Cytotoxity of tumor cells treated with AgFeO2 and Quercetin loaded AgFeO2 under UV light significantly decreased from 65.7 to 27.2% to 23.58, and 7.6%, respectively. The results suggest that AgFeO2 is a suitable nanocarrier to be used in drug delivery and photodynamic therapy.