The current experiment was conducted in order to evaluate the addition of Yaghooti Grape Methanolic Extraction, Mealand Juice with commercial Antioxidant on Humoral Immune Response against Newcastle and Avian Influenza Viruses in Broilersat day 21 and 42. 150 day-old Ross 308 (mixed sex) were used in 5 replicates, 3 replicates and 10 chicks per replicate for 42 days in completely randomized design manner. Experimental treatments were 1) control (with no additive); 2) basal diet with 150 ml/kg grape juice; 3) basal diet with 30 g/kg grape meal; 4) basal diet with 30 mg/L of grape juice and 5) basal diet with 200 mg/kg BHT. Results showed that grape juice and BHT treatments were significantly increased the ND titer at day 21, compared with control. BHT treatment showed significantly higher antibody titers against AI at day 42. Grape juice, meal and BHT have increased the AI titers at day 42, compared to control. It can be concluded that using 30 ml/kg grape juice have positive effects on antibody titers against Newcastle and Avian Influenza at day 21 and using 200 mg/kg BHT has significantly improved the ND and IBD titers.
